Including Publications Prior to 1998

All Publications:

IN PREPARATION

Shoemaker, R.H., Halliday, S. Fletcher, T., Buckheit, R. and Sausville, E.A. Characterization of a quantitative PCR-based assay for agents active against human herpesvirus 8. In preparation.

Huang, M., Buckheit, R.W.,Jr., Turpin, J.A., and Rice, W.G., Identification of a benzoylmethylindolepyridinium derivative as a broadly antiretroviral nonnucleoside reverse transcriptase inhibitor. In preparation.

1999

Kodihalli, S. D. Kobasa and R.G. Webster: Strategies for inducing protection against avian influenza A subtypes with DNA vaccines. (In press Vaccine)

Garcia, A.C., De Clerq, E., Pannecouque, C., Witvrouw, M., Stup, T.L.,Turpin, J.A., Buckheit, R.W., Jr. and Cushman, M. Synthesis and anti-HIV activity of cosalane analogs incorporating nitrogen in the linker chain. Submitted. 1999.

Stoddart, C.A., Moreno, M.E., Linquist-Stepps, V.D., Bare, C., Bogan, M.R., Gobbi, A., Buckheit, R.W., Jr., Bedard, J., Rando, R.F., and McCune, J.M. Antiviral activity of dOTC (BCH-10652) against 3TC-resistant human immunodeficieny virus type 1 in SCID-hu thy/liv mice. Submitted. 1999.

Quan, Y., Motakis, D., Buckheit, R.W., Jr., Xu, Z.Q.,. Flavin, M.T., Parniak, M.A. and Wainberg, M.A. Sensitivity and resistance to (+)-calanolide A of wild type and mutated forms of HIV-1 reverse transcriptase. Antiviral Therapy. In press. 1999.

Halliday, S.M., Russell, J.D., Osterling, M.C. and Buckheit, R.W., Jr. Therapeutic Potential of the phosphorothioate oligonucleotide ISIS 5320: Topical and combination anti-HIV use. Submitted. 1999.

Morningstar, M.L., Roth, T., Kroeger Smith, M., Zajac, M., Watson, K.,Buckheit, R.W., Jr. and Michejda, C.J. Synthesis and biological activity of potent non-nucleoside inhibitors of HIV-1 reverse transcriptase that retain activity against mutant forms of the enzyme. Submitted. 1999.

Huang, M., Buckheit, R.W., Jr., Turpin, J.A. and Rice, W.G. Identification of a benzoylmethylindolepyridinium (BMIP) derivative as a broadly antiretroviral nonnucleoside reverse transcriptase inhibitor. Submitted. 1999.

Xu, Ze-Qi, Buckheit, R.W., Jr., Stup, T.L., Flavin, M.T., Khilevich, A., Lin, L. and Zembower, D.E. In vitro anti-human immunodeficiency virus (HIV) activity of the chromanone derivative, 12-oxocalanolide A, a novel NNRTI. In press. 1999

Rice, W.G., Schaeffer, C.A., Summers, M.F., Turpin, J.A., Huang, M.and Buckheit, R.W., Jr. Identification of an inhibitor of the human immunodeficiency virus nucleocapsid protein zinc finger as a candidate for usage as a topical microbicide to prevent sexual transmission. Submitted. 1999.

Lewis, MG, Yalley-Ogunro, J, Greenhouse, JJ, Brennan, TP, Bo Jiang, J, Vancott, TC, Lu, YC, Eddy, GA and Birx, BL. Limited Protection from a Pathogenic Chimeric Simian-Human Immunodeficiency Virus Challenge Following Immunization with Attenuated Simian Immunodeficiency Virus. J. Virol. 73:1262-1270, 1999

Mascola, JR, Lewis, MG, Stiegler, G, Harris, D, VanCott, TC, Louder, M, J, Brown, CR, Sapan, CV, Frankel, S, Robb, M, Lu, YC, Katinger, H and Birx, D. Protection of macaques against SHIV-89.6p by passive transfer of neutralizing antibodies. J. Virol. 73:4009-4018, 1999

Buckheit, R.W., Jr., White, E.L., Fliakas-Boltz, V., Russell, J., Stup, T.L., Kinjerski, T.L., Osterling, M.C., Weigand, A. and Bader, J.P. Unique anti-human immunodeficiency virus activity of the nonnucleoside reverse transcriptase inhibitors calanolide A, costatolide and dihydrocostatolide. Antimicrobial Agents Chemoth. 43:1827-1834. 1999.

Buckheit, R.W., Jr., Russell, J.D., Pallansch, L.A. and Driscoll, J.S. Anti-HIV-1 Activity of 2’-fluoro-2’,3’-dideoxyarabinosyladenine (F-ddA) used in combination with other mechanistically diverse inhibitors of HIV-1 replication. Antiviral Chem.Chemotherapy. 10:115-119. 1999.

Ruell, J.A., De Clerq, E., Pannecouque, C., Witvrouw, M., Stup, T.L.,Turpin, J.A., Buckheit, R.W., Jr. and Cushman, M. Synthesis and anti-HIV activity of cosalane analogs with substituted benzoic acid rings attached to the pharmacophore through methylene and amide linkers. J.Org. Chem. 64: 5858-5866. 1999.

Zaharevitz, D.W., Gussio, R., Jalluri, R., Patabiraman, P., Pallansch, L.A., Weigand, A. and Buckheit, R.W., Jr. Combination of 3D database searching and 3D QSAR in the discovery of novel inhibitors of HIV-1 reverse transcriptase. Manuscript in preparation. 1999.

Yang, S., Buckheit, R.W., Jr., Cragg, G.M., Bader, J.P., McCloud, T., Clanton, D., Boyd, M.R., Newman, D. and Sauseville, E.A. Natural product based anti-HIV drug discovery. Manuscript in preparation. 1999.

Casimiro-Garcia, A., Micklatcher, M., Turpin, J.A., Stup, T.L., Watson, K., Buckheit, R.W., Jr. and Cushman, M. Novel modifications in the alkenyldiarylmethane (ADAM) series of nonnucleoside reverse transcriptase inhibitors. Submitted. 1999.

Turpin, J. A., Song, Y., Inman, J. K., Huang, M., Wallqvist, A., Maynard, A., Covell, D.G., Rice, W.G., and Appella, E. Synthesis and biological properties of novel pyridinioalkanoyl thiolesters (PATE) as anti-HIV-1 agents that target the viral nucleocapsid protein zinc fingers. J. Med. Chem.42: 67. 1999.

Cushman, M., S. Insaf, G. Paul, E. De Clercq, D. Schols, C. Pannccouque, M. Witrouw, C. A. Schaeffer, J. A. Turpin and W. G. Rice. Extension of the polyanionic cosalane pharmacophore as a strategy for increasing anti-HIV potency. J. Med. Chem. 42: 1767. 1999.

Lin, Z., N. Neamati, N, Kiryu, Y., J. A. Turpin, C. Aberham, K. Strebel, K. Kohn, W. G. Rice, Y. Pommier and T. R. Burke, Jr. Chicoric acid analogues as HIV-1 integrase inhibitors. J. Med. Chem. 42:1401, 1999.

Howard, O. M. Z., A.-K. Shirakawa, Turpin, J.A., A. Maynard, G. J. Tobin, M. Carrington, J. J. Oppenheim and M. Dean. Naturally occurring CCR5 Extracellular and transmembrane domain variants affect HIV-1 co-receptor and ligand binding function. J. Biol. Chem. 274:16228. 1999.

Garcia, A. C., E. de Clerq, C. Pannecouque, M. Witvrouw, T. L. Stup, J. A. Turpin, R. W. Buckheit, Jr. and M. Cushman. Synthesis and anti-HIV activity of cosalane analogs with substitute benzoic acid rings attached to. 1999.

Turpin, J. A., S. J. Terpening, C. Schaeffer, K. Williamson, C. Palamone, L. Graham and W. G. Rice. Prolonged loss of HIV-1 infectivity after treatment of productively infected monocyte/macrophages (Mo/M) with a retroviral zinc finger inhibitor. J. Virol. Submitted. 1999.

Neamati, N., Lin, Z., H. E. Winslow, H. Zhao, J. A. Turpin, C. Aberham, A. Orr, K. Strebel, W. G. Rice, T. R. Burke, Jr., and Y. Pommier. Design and synthesis of novel HIV-1 integrase inhibitors with antiviral activity: a remarkable metal-dependent inhibition of HIV-1 integrase by salicylhydrazides. J. Med. Chem. Submitted. 1999.

Neamati, N., J. A. Turpin, H. E. Winslow, J. L. Christensen, K. Williamson, A. Orr, W. G. Rice, and Y. Pommier. Thiazolothiazepine inhibitors of HIV-1 integrase. J. Med. Chem. Submitted. 1999.

Govorkova, E.A., S. Kodihalli, I.V. Alymova, B. Fanget and R.G. Webster: Growth and immunogenicity of influenza viruses cultivated in Vero, MDCK cells and embryonated chicken eggs. Brown, F. Robertson, J.S. and J.M. Woods. (eds) Inactivated Influenza Vaccine prepared in Cell Culture. Dev. Biol. Stand Basel, Karger, Vol 98, pp 39-51, 1999.

Kodihalli, S. H. Goto, D. Kobasa, S. Krauss, Y. Kawaoka, and R.G. Webster: DNA vaccine encoding hemagglutinin provides protective immunity in mice against H5N1 influenza virus. J.Virol. 73:2094-2098, 1999.

Kobasa, D., S. Kodihalli, M. Luo, M. R. Castrucci, I. Donatelli, Y. Suzuki, T. Suzuki and Y. Kawaoka: Amino acid residues contributing to the substrate specificity of the influenza A virus neuraminidase. J. Virol. 73: 6743-51, 1999.

Buckheit, R.W., Jr., Lackman-Smith, C., Snow, M.J., Halliday, S.M., Agrawal, V.K. and Broom, A.D. PMTI, a broadly active unusual single stranded polyribonucleotide, inhibits HIV replication by two distinct mechanisms. Antiviral Chem.Chemotherapy. In press. 1999.

Turpin, J.A., Young, S., Inman, J., Huang, M., Whalqvist, A., Maynard, A., Covell, D.G., Rice, W.G., and Appella, E., Synthesis and biological properties of novel pyridinioalkanoyl thiolesters (PATE) as anti-HIV-1 agents that target the viral nucleocapsid protein zinc fingers. J. Med Chem 42: 67-86. 1999

1998

White, E.L., Rose, L.M., Allan, P.W., Buckheit, R.W., Jr., Shannon, W.M. and Secrist, J.A., III. Polyamine pools in human immunodeficiency virus infected cells. J. Acq. Immunodef. Syndromes and Human Retrov. 17:101-103. 1998.

Cushman, M., Casimiro-Garcia, A., Hejchman, E., Ruell, J.A., Huang, M., Schaeffer, C.A., Willimson, K., Rice, W.G. and Buckheit, R.W., Jr. New alkenyldiarylmethanes with enhanced potencies as anti-HIV agents which act as non-nucleoside reverse transcriptase inhibitors. J. Med. Chem. 41:2076-2089. 1998.

Turpin, J.A., Buckheit, R.W., Jr., Derse, D., Hollingshead, M., Williamson, K., Palamone, C., Osterling, M.C., Hill, S.A., Graham, L., Schaeffer, C.A., Bu, M., Huang, M., Cholody, W.M., Michejda, C.J., and Rice, W.G. Inhibition of acute, latent and chronic phase HIV-1 replication by a bistriazoloacridone analog that selectively inhibits HIV-1 transcription. Antimicrob. Agents Chemother. 42:487-494. 1998.

Rininger, J.A., Miller, S.B., Ma, X., Chigurpati, P., Calabreses, C., Standish, L., Wells, K., Steadle-Foster, L., Buckheit, R.W., Jr. and Babish, J.G. Preliminary, open-label, safety and efficacy study of the novel kinase inhibitor andrographolide in asymptomatic human immunodeficiency virus-infected individuals. Submitted. 1998.

Tutonda, M.G., Buckheit, R.W., Jr., Agrawal, V.K. and Broom, A.D. Antiviral oligo and polyribonucleotides containing selected triazol[2,3-a] purines. J. Med. Chem. 41:4958-4964. 1998.

O’Keefe, B.R., Erim, T., Beutler, J.A., Cardellina, J.H. III, Gulakowski, R.J., Krepps, B.L., McMahon, J.B., Sowder, R.C. II, Johnson, D.G.,Buckheit, R.W., Jr., Stup, T.L. and Boyd, M.R. Isolation and characterization of adociavirin, a novel HIV-inhibitory protein from the sponge Adocia sp. FEBS Letter. 431:85-90. 1998.

Howard, O.M.Z., Oppenheim, J.J., Hollingshead, M.G., Covey, J.M., Bigelow, J., McCormack, J.J., Buckheit, R.W., Jr., Clanton, D.J.,Turpin, J.A. and Rice, W.G. Inhibition of in vitro and in vivo HIV replication by a distamycin analog that interferes with chemokine receptor function: A candidate for chemotherapeutic and microbicidal application. J. Med. Chem. 41:2184. 1998.

Langlois, AJ, Desrosiers, RC, Lewis, MG, KewalRamani, VN, Littman, DR, Zhou, JY, Manson, K, Wyand, MS, Bolognesi, DP and Montefori, DC. Neutralizing antibodies in sera form macaques immunized with attenuated simian immunodeficiency virus. J. Virol. 72:6950-6955, 1998.

Huang, M., Zensen, R., Cho, M., and Martin, M. Construction and characterization of a temperature sensitive human immunodeficiency virus type 1 reverse transcriptase mutant. J. Virol. 72:2047-54. 1998

Huang, M., Turpin, J.A., Graham, L. , Janini, G.M., Covell, D.G., Maynard, A., and Rice, W.G. Selectivity of anti-HIV agents for the nucleocapsid zinc finger protein and not other zinc finger proteins. J. Med. Chem. 41:1371-1381. 1998

Cushman, M., Casimiro-Garcia, A., Hejchman, E., Ruell, J.A., Huang,M., Williamson, K., Rice, W.G., Buckheit, R.W.,Jr. New Alkenyldiarylmethanes (ADAMS) with enhanced potencies as anti- HIV agents which act as non-nucleoside reverse transcriptase inhibitors. J Med Chem 41:2076-89. 1998.

Maynard, A., Huang, M., Rice, W.G., and Covell, D.G. Reactivity of the HIV-1 NCp7 zinc finger domains from the perspective of density-functional theory. PNAS, 95:11578-11583. 1998

Palmer, S., Alaeus, A., Albert, J. and Cox, S. Drug Susceptibility of Subtypes A, B, C, D, and E Human Immunodeficiency Virus Type 1 Primary Isolates. AIDS Res. Hum. Retroviruses 14(2): 157-162. 1998.

Shafer, R. W., Winters, M. A., Palmer, S., and Merigan, T. C. Multiple concurrent reverse transcriptase and protease mutations and multidrug resistance in HIV-1 isolates from heavily treated HIV-1 infected patients. Ann. Intern. Med. 128(11) 1998.

Palmer, S. Rationalizing salvage therapy. GMHC Treatment Issues 12(6) 1998.

Palmer, S., Shafer, R. and Merigan, T. C. Highly drug-resistant human immunodeficiency virus type 1 clinical isolates are cross-resistant to many antiretroviral compounds in current clinical development. AIDS “submitted” 1998.

Palmer, S., Shafer, R. and Merigan, T. C. Both nucleoside and nucleotide analogs are potentiated by hydroxyurea against drug-susceptible and drug-resistant HIV isolates. Antimicrob. Agents Chemother. “submitted” 1998.

Palmer, S., Shafer, R. and Merigan, T. C. New drug combinations against highly drug resistant HIV isolates in Vitro. Manuscript in progress. 1998.

Gong, W., O. M. Z. Howard, J. A. Turpin, M. C. Grimm, H. Ureda, P. Gray, C. J. Raport, J. J. Oppenheimer, and J. M. Wang. Monocyte chemotactic protein (MCP)-2 activates CCR5 and blocks CD4/CCR5-mediated HIV-1 entry/replication. J. Biol. Chem. 273:4289. 1998.

Huang, M., J. A. Turpin, A. Maynard, L. Graham, G. M. Janini, D. G. Covell and W. G. Rice. Anti-HIV agents that selectively target retroviral nucleocapsid protein zinc fingers without affecting cellular zinc finger proteins. J. Med Chem. 41:1371.1998

Howard, O. M. Z., T. Korte, N. Tarasova, M. Grimm, J. A. Turpin, W. G. Rice, C. J. Michejda, R. Blumenthal and J. J. Oppenheim. Small molecule inhibitor of HIV-1 cell fusion blocks chemokine receptor mediated function. J. Leukocyte Biol. 64:6. 1998.

Montefiori, DC, Reimann, KA, Wyand, MS, Manson, K, Lewis, MG, Collman, RG, Sodroski, JA, Bolognesi, DP and Letvin, NL. Neutralizing antibody responses in macaques infected with chimeric simian-human immunodeficiency virus (SHIV) containing the envelope glycoprotein of either a laboratory-adapted variant or primary isolate of human immunideficiency virus type 1. J. Virol.72:3427-3431, 1998

Alymova, I.V., S. Kodihalli, E.A Govorkova, B. Fanget, C. Gerdil, and R.G. Webster: Immunogenicity and Protective efficacy in mice of influenza B vaccines grown in mammalian cells or embryonated chicken eggs. J.Virol. 72:4472-4477, 1998.

Shortridge, K.F. N.N. Zhou, P. Gao, T. Ito, Y. Kawaoka, S. Kodihalli, S. Krauss, D. Markwell, K. G. Murti, M. Morwood, D. Senne, L. Sims, A. Takada, Yi. Guan and Robert G. Webster. Characterization of avian H5N1 influenza viruses from poultry in Hong Kong. Virology. 331-342. 1998.

1997

Buckheit, R.W., Jr. Specialized anti-HIV testing: Expediting preclinical drug development. Drug Information Journal. 31:13-22. 1997.

Kinjerski, T.L. and Buckheit, R.W., Jr. The role of genotypic heterogeneity in wild type virus populations on the selection of nonnucleoside reverse transcriptase inhibitor-resistant viruses. Antiviral Res. 33: 109-115. 1997.

Gulakowski, R.J., McMahon, J.B., Buckheit, R.W., Jr., and Boyd, M.R. Biological survey of the anti-HIV activity of prostratin. Antiviral Res. 33: 87-98. 1997.

Rice, W.G., Baker, D., Schaeffer, C.A., Graham, L., Bu, M., Terpening, S., Clanton, D., Schultz, R., Bader, J.P., Buckheit, R.W., Jr., andTurpin, J.A. Inhibition of multiple phases of HIV-1 replication by a dithiane compound that attacks the conserved zinc fingers of retroviral nucleocapsid proteins. Antimicrob. Agents Chemother. 41:419-426. 1996

Driscoll, J.S., Mayers, D.L., Bader, J.P., Weislow, O.S., Johns, D.G. andBuckheit, R.W., Jr.,. 2′-Fluoro-2′,3′-dideoxyarabinosyladenine (F-ddA), Activity against drug resistant HIV strains and clades A-E. Antiviral Chem. Chemother. 8:107-111. 1997.

Buckheit, R.W., Jr., Hollingshead, M., Stinson, S., Fliakas-Boltz, V.,Pallansch, L.A., Roberson, J., Decker, W., Elder, C., Borgel, S., Bonomi, C., Shores, R., and Bader, J.P. Efficacy, pharmacokinetics, and in vivo antiviral activity of UC781, a highly potent, orally bioavailable nonnucleoside reverse transcriptase inhibitor. AIDS Res. Hum. Retrov. 13:789-796. 1997.

Buckheit, R.W., Jr., Snow, M.J., Fliakas-Boltz, V., Kinjerski, T.L., Russell, J.D., Snow, M., Pallansch, L.A., Brouwer, W.G., and Yang, S.S. Characterization of structurally-related anti-human immunodeficiency virus UC analogs: Highly potent nonnucleoside reverse transcriptase inhibitors with efficacy against NNRTI-resistant virus isolates. Antimicrobial Agents Chemother. 41:831-837. 1997.

Rice, W.G., Turpin, J.A., Huang, M., Clanton, D., Buckheit, R.W., Jr., Covell, D.G., Wallqvist, A., McDonnell, N.B., De Guzman, R.N., Summers, M.F., Zalkow, L., Bader, J.P., Haugwitz, R.D., and Sausville, E.A. Azodicarbonamide inhibits HIV-1 replication by targeting the nucleocapsid protein. Nature Medicine 3:341-345. 1997.

Zembower, D.E., Liao, S., Flavin, M.T., Xu, Z-Q., Stup, T.L., Buckheit, R.W., Jr., Khilevich, A., Mar, A. and Sheinkman, A.K. Structural analogues of the calanolide anti-HIV agents. Modification of the trans-10,11-dimethyldihydropyran-12-ol ring (Ring C). J. Med. Chem. 40:1005-1017. 1997.

Boyd, M.R., Gustafson, K.R., McMahon, J.B., Shoemaker, R.H., O’Keefe, B.R., Mori, T., Gulakowski, R.J., Wu, L., Rivera, M.I., Laurencot, C.M., Cardellina II, J.H., Buckheit, R.W., Jr., Nara, P.L., Pannell, L.K., Sowder II, R.C. and Henderson, L.E. Discovery of cyanovirin-N, a novel HIV (human immunodeficiency virus)-inactivating protein that binds viral surface envelope glycoprotein gp120; Potential applications to microbicide development. Antimicrob. Agents Chemother. 41:1521-1530. 1997.

Roth, T., Morningstar, M.L., Boyer, P.L., Hughes, S.H., Buckheit, R.W., Jr., Michejda, C.J. Synthesis and biological activity of novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 2-Aryl-substituted benzimidazoles. J. Med. Chem. 40:4199-4207. 1997.

Tutonda, M.G., Fain, H.D., Buckheit, R.W., Jr. and Broom, A.D. The role of hydrophobic versus hydrophilic base character in the anti-HIV activity of purine-containing polyribonucleotides. J. Med. Chem. 16:173-182. 1997.

Kroeger Smith, M.B., Michejda, C.J., Hughes, S.H., Boyer, P.L., Janssen, P.A.J., Andries, K., Buckheit, R.W., Jr., and Smith, R.H. Molecular modeling of HIV-1 reverse transcriptase drug-resistant mutant strains: Implications for the mechanism of polymerase action. Protein Eng. 10:1379-1383. 1997.

Yang, S.S., Pattabiraman, N., Gussio, R., Pallansch, L.A., Buckheit, R.W., Jr. And Bader, J.P. Cross-resistance analysis and molecular modeling of nonnucleoside reverse transcriptase inhibitors targeting drug-resistance mutations in the reverse transcriptase of human immunodeficiency virus. Leukemia. In press. 1997

Fong, S.E., Greenwood, J.D., Williamson, J.C., Derse, D., Pallansch, L.A., Copeland, T., Rasmussen, L., Nagashima, K., Tobin, G., and Gonda, M.A. Bovine immunodeficiency virus tat gene: cloning of two distinct cDNAs and identification, characterization, and immunolocalization of the tat gene products. J. Virol. In press. 1997.

Buckheit, R.W., Jr., Hollingshead, M., Stinson, S., Fliakas-Boltz, V.,Pallansch, L.A., Roberson, J., Decker, W., Elder, C., Borgel, S., Bonomi, C., Shores, R., and Bader, J.P. Efficacy, pharmacokinetics, andin vivo antiviral activity of UC781, a highly potent, orally bioavailable nonnucleoside reverse transcriptase inhibitor. AIDS Res. Human Retrov. 13(9):789-796. 1997.

Buckheit, R.W., Jr., Snow, M.J., Fliakas-Boltz, V., Kinjerski, T.L., Russell, J.D., Snow, M., Pallansch, L.A., Brouwer, W.G., and Yang, S.S. Characterization of structurally-related anti-human immunodeficiency virus UC analogs: Highly potent nonnucleoside reverse transcriptase inhibitors with efficacy against NNRTI-resistant virus isolates. Antimicrobial Agents Chemother. 41:831-837. 1997.

Buckheit, R.W., Jr., Fliakas-Boltz, V., Kinjerski, T.L., Russell, J.D. andPallansch, L.A. Highly potent UC analogs with efficacy against NNRTI-resistant viruses. The Fourth Conference on Retroviruses and Opportunistic Infections. Washington, D.C., January 22-26. . 1997

Fliakas-Boltz, V., Pallansch, L.A., and Buckheit, R.W., Jr. A diarylsulfone nonnucleoside reverse transcriptase inhibitor with a unique sensitivity profile to drug resistant virus isolates. The Fourth Conference on Retroviruses and Opportunistic Infections. Washington, D.C., January 22-26. 1997

Buckheit, R.W., Jr., Fliakas-Boltz, V., Kinjerski, T.L., Russell, J.D. andPallansch, L.A. Highly potent UC analogs with efficacy against NNRTI-resistant viruses. Tenth International Conference on Antiviral Research. Atlanta, Georgia, April 6-11. 1997

Rosenberg, YJ, Lewis, MG, Greenhouse, JJ, Cafaro, A, Leon, EC, Brown, CR, Bieg, KE and Kosco-Vilbois, MH. Enhanced follicular dendritic cell-B cell interaction in HIV and SIV infections and its potential role in polyclonal B cell activation. Eur. J. Immunol. 27:3214-3222, 1997

Rosenberg, YJ, Cafaro, A, Brennan, T, Greenhouse, JG, McKinnon, K, Bellah, S, Yalley-Ogunro, J, Gartner, S and Lewis, MG. Characterization of the CD8+ Lymphocytosis during primary SIV infections. AIDS 11:959-968, 1997

Rosenberg, YJ, Cafaro, A, Brennan, T, Greenhouse, JJ, Villinger, F, Ansari, AA, Brown, C, McKinnon, K, Bellah, S, Yalley-Ogunro, J, Elkins, WR, Gartner, S and Lewis, MG. Virus induced cytokines regulate circulating lymphocyte levels during primary SIV infections. Int. Immunol. 9:703-712, 1997

Ono, A., Huang, M. and E. Freed. Characterization of human immunodeficiency virus type 1 matrix revertants: effects on virus assembly, gag processing, and env incorporation into virions. J. Virol.71:4409-4418. 1997.

Huang, M. and M. Martin. Incorporation of Pr160gag-pol into virus particles requires the presence of both the major homology region and adjacent C-terminal capsid sequences within the Gag-Pol polyprotein.J. Virol. 71:4472-4478. 1997.

Palmer, S., and Cox, S. Increased activation of the combination of 3′-azido-3′-deoxythymidine and 2′-deoxy-3′-thiacytidine in the presence of hydroxyurea. Antimicrob. Agents Chemother. 41(2): 460-464. 1997.

Anderson, M.J., Porter, D.C., Moldoveanu, Z., Fletcher III, T.M., McPherson, S., and Morrow, C.D. Characterization of the expression and immunogenicity of poliovirus replicons that encode simian immunodeficiency virus SIV mac239 Gag or envelope SU proteins. AIDS Res Hum Retroviruses 13: 53-62. 1997

Fletcher III, T.M., Soares, M.A., McPherson, S., Hui, H., Wiskerchen, M., Muesing, M., Shaw, G., Leavitt, A.D., Boeke, J.D., and Hahn, B.H. Complementation of integrase function in HIV-1 virions. EMBO.16: 5123-5138. 1997.

Turpin, J. A., C. A. Schaeffer, S. J. Terpening, L. Graham, M. Bu and W. G. Rice. Reverse transcription of human immunodeficiency virus type 1 is blocked by retroviral zinc finger inhibitors. Antiviral Chem. and Chemother. 8:60. 1997.

Warren, K. M., W. L. Rose, J. L. Cone, W. G. Rice and J. A. Turpin. Differential infection of CD34+ cell-derived dendritic cells and monocytes with lymphocyte-tropic and monocyte-tropic HIV-1 strains. J. Immunol. 158:5035. 1997.

McDonnell, N. B., R. N. De Guzman, W. G. Rice, J. A. Turpin and M. F. Summers. Zinc-ejection as a new rationale for the use of cystamine and related disulfide-containing antiviral agents in the treatment of AIDS. J. Med. Chem. 40:1969. 1997.

Kodihalli, S.Kodihalli, S., J.R. Haynes, H.L. Robinson, and R.G. Webster: Cross protection among lethal H5N2 influenza viruses induced by DNA vaccine to the hemagglutinin. J. Virol. Vol 71:3391-3396, 1997.

Kodihalli, S. and R.G. Webster: DNA vaccines for avian influenza-a model for future poultry vaccines? Proceedings of the Fourth International Symposium on Avian Influenza, pp 263-280. Athens, Georgia , May 28-31, 1997.

1996

Kinjerski, T.L., Pallansch, L.A. and Buckheit, R.W., Jr. Isolation and characterization of HIV-1 isolates resistant to oxathiin carboxanilide derivatives: Evaluation of variables in the selection process. Antiviral Chem. Chemother. 7:261-269. 1996.

Buckheit, R.W., Jr., Fliakas-Boltz, V., Russell, J.D., Snow, M.,Pallansch, L.A., Yang, S.S., Bader, J.P., Khan, T.N., and Zanger, M. A diarylsulfone nonnucleoside reverse transcriptase inhibitor with a unique sensitivity profile to drug-resistant virus isolates. Antiviral Chem. Chemother. 7:243-252. 1996.

Turpin, J.A., Schaeffer, C.A., Bu, M., Graham, L., Buckheit, R.W., Jr., Clanton, D. and Rice, W.G. HIV-1 replication is unaffected by human secretory leukocyte protease inhibitor. Antiviral Res. 29:269-278. 1996.

McMahon, J.B., Buckheit, R.W., Jr., Gulakowski, R.J., Currens, M.J., Vistica, D.T., Shoemaker, R.H., Stinson, S.F., Russell, J.D., Bader, J.P., Narayanan, V.L., Shultz, R.J., Brouwer, W.G., Felauer, E.E., and Boyd, M.R. Biological and biochemical anti-HIV activity of UC38, a new nonnucleoside reverse transcriptase inhibitor. J. Pharmacol. Exptl. Ther. 276:298-305. 1996.

Cushman, M., Golebiewski, W.M., Graham, L., Turpin, J.A., Rice, W.G., Fliakas-Boltz, V. and Buckheit, R.W., Jr. Synthesis and biological evaluation of certain alkenyldiarylmethanes (ADAMs) as anti-HIV-1 agents which act as non-nucleoside reverse transcriptase inhibitors. J. Med. Chem. 39:3217-3227. 1996.

Currens, M.J., Gulakowski, R.J., Mariner, J.M., Moran, R.A., Buckheit, R.W., Jr. Gustafson, K.R., McMahon, J.B., and Boyd, M.R. Antiviral activity and mechanism of action of calanolide A against the human immunodeficiency virus. J. Pharmacol. Exptl. Ther. 279:645-651. 1996.

Halliday, S.H., Lackman-Smith, C., Decker, W.D., Bader, J.B., Rice, W., Clanton, D.J. and Buckheit, R.W., Jr. Inhibition of HIV replication by the sulfonated dye resobene. Antiviral Res. 33:41-53. 1996.

Rice, W.G., Turpin, J.A., Schaeffer, C.A., Graham, L., Clanton, D.,Buckheit, R.W., Jr., Zaharevitz, D., Summers, M.F., Wallqvist, A. and Covell, D.G. Evaluation of selected chemotypes in coupled cellular and molecular target-based screens identifies novel HIV-1 zinc-finger inhibitors. J. Med. Chem. 39:3606-3616. 1996.

Novembre, FJ, Lewis, MG, Saucier, MM, Yalley-Ogunro, J, Brennan, T, McKinnon, K, Bellah, S, and McClure, HM. Deletion of the SIVsmmPBj nef gene abrogates the ability to induce acutely lethal disease in pig-tailed macaques. AIDS Res. Human Retroviruses 12:727-736, 1996.

Gummuluru, S, Novembre, FJ, Lewis, MG, Gelbard, HA and Dewhurst, S. Apoptosis correlates with immune activation in intestinal lymphoid tissues from macaques acutely infected by a highly enteropathic simian immnodeficiency virus, SIVsmmPBj14. J. Virol. 225:21-32, 1996

Palmer, S., Rasmussen, H., Harmenberg, J. and Cox, S. Intracellular metabolism of 3′-azido-3′-deoxythymidine in the presence of ganciclovir or foscarnet. Antiviral Chem. Chemother. 7(1): 14-20. 1996.

Palmer, S., Harmenberg, J. and Cox, S. Synergistic inhibition of HIV isolates (including 3′-azido-3′-deoxythymidine -resistant isolates) by foscarnet in combination with 2′,3′-dideoxyinosine or 2′,3′-dideoxycytidine. Antimicrob. Agents Chemother. 40(5): 1285-1288. 1996.

Berke, S., Palmer, S., Bergman, T., Wester, D., Svedmyr, J., Linder, S., Jörnvall, H., and Dalianis, T. A short peptide eluted from the H-2Kb molecule of a polyomavirus-positive tumor corresponds to polyomavirus large T antigen peptide at amino acids 578 to 585 and induces polyomavirus-specific immunity. J. Virol. 70(5): 3093-3097. 1996.

Gray, W.L., Gusick, N.J., Ek-Kommonen, C., Kempson, S., and Fletcher III, T.M. The inverted repeat regions of the simian varicella virus and varicella zoster virus genomes have a similar genetic organization. Virus Research. 39: 181-193. 1996.

Fletcher III, T.M., Brichachek, B., Sharova, N., Newman, M., Stivahtis, G., Sharp, P.M., Emerman, M., Hahn, B.H., and Stevenson, M. Nuclear import and cell cycle arrest functions of the HIV-1 Vpr protein are encoded by two separate genes in HIV-2/SIVsm. EMBO. 15: 6155-6165. 1996.

Rice, W. G., Arthur, L. O., Henderson, L. E., and Turpin, J. A., Discovery and development of disulfide-substituted benzamides as candidate anti-HIV drugs. International Antiviral News 4:3. 1996.

Cushman, M., Golebiewski, W. M., Graham, L., Turpin, J. A., Rice, W. G., Fliakas-Boltz, V., and Buckheit, R. W. Jr. Synthesis and biological evaluation of certain alkenyldiarylmethanes (ADAMs) as anti-HIV-1 agents which act as non-nucleoside reverse transcriptase inhibitors. J. Med. Chem. 38:3217. 1996.

Turpin, J. A., Terpening, S. J., Schaeffer C. A., Yu, G., Glover, C. J., Felsted, R. L., Sausville,E.A., and Rice, W. G., Inhibitors of human immunodeficiency virus type 1 zinc fingers prevent normal processing of Gag precursors and result in the release of non-infectious virus particles. J. Virol. 70: 6180. 1996.

Rice, W. G. and Turpin, J. A. Virus-encoded zinc fingers as targets for antiviral chemotherapy. Rev. Med. Virol. 6:187. 1996.

Rice, W. G., Turpin, J. A. Schaeffer, C. A., Graham, L., Clanton. D.,Buckheit, R. W., Jr., Zaharevitz, D., Summers, M. F., Wallqvist, A. and Covell, D. Evaluation of selected chemotypes in coupled cellular and molecular target-based screens identifies novel HIV-1 zinc finger inhibitors. J. Med. Chem. 19:3606. 1996.

Reuben, J. M., Turpin, J. A., Lee, B.-N., Doyle, M., Gonik, B., Jacobson R. J. and Shearer, W. T. Induction of inflammatory cytokines in placental monocytes of gravidae infected with the human immunodeficiency virus type 1. J. Interferon and Cytokine Res. 16:963. 1996.

1995

McMahon, J.B., Currens, M.J., Gulakowski, R.J., Buckheit, R.W., Jr., Lackman-Smith, C., Hallock, Y.F. and Boyd, M.R. Michellamine B, a novel plant alkaloid, inhibits human immunodeficiency virus-induced cell killing by two distinct mechanisms. Antimicrob. Agents Chemother. 39:484-488. 1995.

Buckheit, R.W., Jr., Fliakas-Boltz, V., Decker, W.D., Roberson, J.L., Stup, T.L., Pyle, C.A., White, E.L., McMahon, J.B., Currens, M.J., Boyd, M.R. and Bader, J.P. Comparative anti-HIV evaluation of diverse HIV-1-specific reverse transcriptase inhibitor-resistant virus isolates demonstrates the existence of distinct phenotypic subgroups. Antiviral Res. 26:117-132. 1995.

Ecker, D.J., Wyatt, J.R., Vickers, T., Buckheit, R., Roberson, J., and Imbach, J-L. Novel guanosine quartet structure binds to the HIV envelope and inhibits envelope mediated cell fusion. Nucleosides and Nucleotides. 14: 1117-1127. 1995.

Clanton, D.J., Rice, W.G., Buckheit, R.W., Jr., Terpening, S.J., Mongelli, N., Borgia, A.L. and Bader, J.P. A novel series of sulfonated and phosphonated derivatives of distamycin which inhibit the replication of HIV. Antiviral Res. 27: 335-354. 1995.

Buckheit, R.W., Jr., Fliakas-Boltz, V., Yeagy-Bargo, S., Weislow, O., Mayers, D.L., Boyer, P., Hughes, S., Chu, H.-S. and Bader, J.P. Resistance to 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives is generated by mutations at multiple sites in the HIV-1 reverse transcriptase. Virology. 210: 186-193. 1995.

Broom, A.D., Agrawal, V.K., Tutonda, M.G., Fain, H.D., and Buckheit, R.W., Jr. Unusual single-stranded polyribonucleotides as potent anti-HIV agents. J. Med. Chem. 38:3253-3257. 1995.

Azad, R.F., Driver, V.B., Buckheit, R.W., Jr., and Anderson, K.P. Antiviral activity of a phosphorothioate oligonucleotide complementary to human cytomegalovirus RNA when used in combination with antiviral nucleoside analogs. Antiviral Res. 28:101-111. 1995.

Rice, W.G., Buckheit, R.W., Jr., Clanton, D, Domagala, J., Gogliotti, R., Bu, M., Graham, L., Schaeffer, C.A., Turpin, J.A., Bader, J.P., Halliday, S.M., Arthur, L.O., and Henderson, L.E. Novel inhibitors of HIV-1 p7NC zinc fingers as candidates for the treatment of AIDS. Science. 270:1194-1197. 1995.

Ojwang, J.O., Buckheit, R.W., Jr., Pommier, Y., Mazumder, A., De Vreese, K., Este, J.A., Pallansch, L.A., Lackman-Smith, C., Wallace, T.L., De Clercq, E., McGrath, M.S. and Rando, R.F. T30177, an oligonucleotide stabilized by an intramolecular guanosine-octet, is a potent inhibitor of laboratory strains and clinical isolates of human immunodeficiency virus type 1. Antimicrob. Agents Chemother. 39:2426-2435. 1995.

Cushman, M., Golebiewski, M., Buckheit, R.W., Jr., and Rice, W.G. Synthesis and biological evaluation of an alkenyldiarylmethane (ADAM) which acts as a novel non-nucleoside HIV-1 reverse transcriptase inhibitor. Bioorg. Med. Chem. Letters. 5:2713-2716. 1995.

Hollingshead, M., Roberson, J., Decker, W., Buckheit, R.W., Jr., Elder, C., Malspeis, L., Mayo, J. and Grever, M. In vivo drug screening applications of HIV-infected cells cultivated within hollow fibers in two physiologic compartments of mice. Antiviral Res. 28:265-279. 1995.

Yang, S.S., Fliakas-Boltz, V., Bader, J.P. and Buckheit, R.W., Jr.Characteristics of a group of nonnucleoside reverse transcriptase inhibitors with structural diversity and potent anti-human immunodeficiency virus activity. Leukemia 9(Suppl 1):S75-S85. 1995.

Kozlowski, P., Buckheit, R.W., Jr. And Jackson, S. Neutralization of HIV infection by serum IgA antibodies. Adv. Exp. Med. Biol. 371:1027-1030. 1995.

Fong, S.E., Pallansch, L.A., Mikovits, J.A., Lackman-Smith, C.S., Ruscetti, F.W., and Gonda, M.A. (1995). cis-Acting regulatory elements in the bovine immunodeficiency virus long terminal repeat. Virology 209:604-614.

Buckheit, R.W., Jr., Kinjerski, T.L., Fliakas-Boltz,V., Russell, J.D., Stup, T.L., Pallansch, L.A., Brouwer, W.G., Dao, D.C., Harrison, W.A., Schultz, R.J., Bader, J.P., and Yang, S.S. Structure-activity and cross-resistance evaluations of a series of human immunodeficiency virus type 1-specific compounds related to oxathiin carboxanilide. Antimicrob. Agents Chemother. 39(12):2718-2727. 1995.

Huang, M., Martin M., and Freed, E. p6Gag is required for particle production from full length human immunodeficiency virus type 1 molecular clones expressing protease. J. Virol. 69:6810-6818. 1995.

Cox, S., Corrigan, G., and Palmer, S. Kinetics and inhibition of reverse transcriptase from AZT-sensitive and -resistant human immunodeficiency virus type 1 by AZT triphosphate. Antiviral Chem. Chemother. 6(2): 123-126. 1995.

Palmer, S., and Cox, S. Intracellular activation and cytotoxicity of three different combinations of 3′-azido-3′-deoxythymidine and 2′,3′-dideoxyinosine. AIDS Res. Hum. Retroviruses 11(10): 1227-1233. 1995.

Newman, M.A., McPherson, S.A., Fletcher III, T.M., Kappes, J.C., and Hahn, B.H. Polyclonal rabbit antisera that detect the Vpr protein of SIVsm and SIVmac on immunoblots of purified virions. AIDS Res Hum Retroviruses 11: 405-408. 1995.

Gray, W.L., Gusick, N., Fletcher III, T.M., and Soike, K.F. Humoral immune response of simian varicella virus infected monkeys to viral antigens. J. Med. Primatol. 24: 246-251. 1995.

Fletcher III, T.M., Wu, X., Liu, H., McPherson, S., Newman, M., Birchachet, B., Sharova, N., Shaw, G.M., Boeke, J.D., Muesing, M.A., Kappes, J.C., Stevenson, M., and Hahn B.H. Virion associated accessory proteins: new targets for antiviral therapy. In: VA Libert, ed. 10th Colloque des Cent Gardes. Paris: Elsevier, p. 99-106. 1995.

Green, S. J., Turpin, J. A. and Nacy, C. A. Cytotoxic effector activities of macrophages. in: Clinical Immunology Principles and Practice, R. R. Rich, T. A. Fleisher, B. D. Schwartz, W. T. Shearer and W. Strober, Eds, Mosby-Year Book Inc., Baltimore, MD. p. 290.1995.

Rice, W. G., Turpin, J. A., Arthur L. O., and Henderson, L. E. Highly conserved retroviral zinc fingers as targets for HIV-1 therapeutic management. International Antiviral News 3:87. 1995.

Kodihalli, S., Justewicz, D.M. Gubereva, L.V., and Webster R.G. Selection of a single amino acid substitution in the hemagglutinin molecule by chicken eggs can render influenza A virus (H3) candidate vaccine ineffective. J. Virol. 69: 4887-4897, 1995.

Kodihalli, S.Kodihalli, S., Justewicz, D.M. Gubereva, L.V., and Webster, R.G. Selection of a single amino acid substitution in the hemagglutinin molecule by the egg renders influenza A (H3) vaccine ineffective. In, R.M. Chanock, F. Brown, H.S. Ginsberg, E. Norrby (eds), Molecular approaches to the control of infectious diseases, pp 381-386. Cold Spring Harbor, New York, 1995.

1994

Buckheit, R.W., Jr., White, E.L., Germany-Decker, J., Allen, L.B., Ross, L.J., Shannon, W. M., Janssen, P.A.J., and Chirigos, M.A. Cell based and biochemical analysis of the anti-HIV activity of combinations of AZT and analogs of TIBO. Antiviral Chemistry Chemoth. 5:35-42. 1994.

Wyatt, J.R., Vickers, T.A., Roberson, J.L., Buckheit, R.W., Jr., Klimkait, T., DeBaets, E., Davis, P.W., Rayner, B., Imbach, J.L., and Ecker, D. G-quartet structure is a potent inhibitor of HIV envelope-mediated cell fusion. Proc. Nat. Acad. Sci. USA. 91:1356-1360. 1994.

McKee, T.C., Cardellina, J.H. II, Riccio, R., Minale, L., Moran, R.A., Gulakowski, R.J., McMahon, J.B., Buckheit, R.W., Jr., Snader, K.M., and Boyd, M.R. HIV inhibitory natural products. 11. Comparative studies of sulfated sterols from marine invertebrates. J. Med. Chem. 37:793-797. 1994.

Boyd, M.R., Hallock, Y.F., Cardellina, J.H., II, Manfredi, K.P., Blunt, J.W., McMahon, J.B., Buckheit, R.W., Jr., Bringmann, G., Zagst, R., Schaffer, M., Cragg, G.M., Thomas, D.W., and Jato, J.G. Anti-HIV michellamines from Ancistrocladus korupensis, a tropical vine from the Cameroonian rainforest; isolation, stereochemistry and biological activity. J. Med. Chem. 37:1740-1745. 1994.

Buckheit, R.W., Jr., Fliakas-Boltz, V., Decker, W.D., Roberson, J.L., Pyle, C.A., White, E.L., Bowdon, B.J., McMahon, J.B., Boyd, M.R., Bader, J.P., Nickell, D.G., Barth, H. and Antonucci, T.K. Biological and biochemical anti-HIV activity of the benzothiadiazine class of nonnucleoside reverse transcriptase inhibitors. Antiviral Res. 25:43-56. 1994.

Buckheit, R.W., Jr., Roberson, J.L., Lackman-Smith, C., Wyatt, J.R., Vickers, T.A., DeBaets, E., Davis, P.W. and Ecker, D.J. Potent and specific inhibition of HIV-envelope-mediated cell fusion and virus binding by a phosphorothioate oligonucleotide (ISIS 5320). AIDS Res Hum. Retrov. 10:1497-1506. 1994.

Cushman, M., Bolebiewski, W.M., McMahon, J.B, Buckheit, R.W., Jr., Clanton, D.J., Weislow, O., Haugwitz, R.D. Bader, J.P. and Rice, W.G. Design, synthesis and biological evaluation of cosalane, a novel anti-HIV agent which inhibits multiple features of virus reproduction. J. Med. Chem. 37:3040-3050. 1994.

Gustafson, K.R., Sowder, R.C., III, Henderson, L.E., Parsons, I.C., Kashman, Y., Cardellina, J.H., II, McMahon, J.B., Buckheit, R.W., Jr., Pannell, L.K. and Boyd, M.R. Circulins A and B, novel HIV-inhibitory macrocyclic peptides from the tropical tree Chassalia parvifolia. J. Amer. Chem. Soc. 116:9337-9338. 1994

Lewis, MG, Bellah, S, McKinnon, K, Yalley-Ogunro, J, Zack, PM, Elkins, WR, Desrosiers, R and Eddy, GA. Titration and characterization of two rhesus derived SIVmac challenge stocks. AIDS Res. Human Retroviruses 10:213-220, 1994.

Rosenberg, YR, Zack, PM, Leon, EC, White, BD, Papermaster, SF, Hall, E, Greenhouse, JJ, Eddy, GA and Lewis, MG. Immunological and Virological changes asssociated with decline in CD4/CD8 ratios in lymphoid organs of SIV-infected macaques. AIDS Res. Human Retroviruses 10:863-872, 1994.

Norton, WN, Brown, CR, Lewis, MG, Rippy, MK, Martin, JE and Zack, PM. Characterization of simian immuodeficiency virus (SIV) infected AA-2 cells by SEM and immunoelecron microscope. Microsc. Res. Tech. 28:430-439, 1994.

Gartner, S. Liu, Y, Polonis, V, Lewis, MG, Elkins, WR, Hunter, EA, Miao, J, Corts, KJ and Eddy, GA. Adaptation of HIV-1 to pig-tailed macaques. J. Med. Primatol. 23:155-163, 1994

Benveniste, RE, Roodman, ST, Hill, RW, Knott, WB, Ribas, JL, Lewis, MG and Eddy, GA. Infectivity of titered doses of simian immunodeficiency virus clone E11S inoculated intravenously into rhesus macaques (Macaca mulatta) J. Med. Primatol. 23:83-88, 1994.

Rosenberg, YJ, Lewis, MG, Leon, EC, Cafaro, A, Eddy, GA and Greenhouse, JJ. Viral DNA burden and decline in percentage of CD4-positive cells in lymphoid compartment of SIV-infected macaques. AIDS Res. Human Retroviruses 10:1269-1277, 1994.

Gartner, S, Liu, Y, Lewis, MG, Polonis, V, Elkins, WR, Zack, PM, Maio, J, Hunter, EA, Greenhouse, JJ and Eddy, GA. HIV-1 infection in pig-tailed macaques. AIDS Res. Human Retroviruses 10:S129-S133, 1994.

Huang, M. and Summers J., (1994). Pet, a small sequence distal to the pregenome cap site, is required for expression of the duck hepatitis B virus pregenome. J. Virol. 68:1564-1567.

Palmer, S., and Cox, S. Comparison of extraction methods for HPLC analysis of deoxynucleotides. J. Chromatogr. A 667: 316-321. 1994.

Palmer, S., and Cox, S. Intracellular metabolism of 3′-azido-3′-deoxythymidine and 2′,3′-dideoxyinosine in combination in the absence and presence of ribavirin. Antiviral Chem. Chemother. 5 (6): 403-409. 1994.

Fletcher III, T.M., and Gray, W.L. Transcriptional analysis of two simian varicella virus glycoprotein genes which are homologous to varicella-zoster virus gpI (gE) and gpIV (gI). Virology 205: 352-359. 1994.

Nelson, B., Danielpour, F. Rossio, J. Turpin, J. A. and Nacy, C. IL-2 suppresses activated macrophage intracellular killing activity by inducing activated macrophages to secrete TGF-. J. Leukocyte Biol. 55:81. 1994.

Turpin, J. A., Fann, S. X., Hansen, B. D., Francis, M. L. Gendelman H. E., and Meltzer, M. S. Regulation of HIV replication in monocytes by interferon. in: Prog. Mol. and Cell. Biol. 14:222. 1994.

Fan, S. X., J. A. Turpin, Aronovitz, J. R. and Meltzer, M. S. Interferon- protects primary macrophages against infection with human immuno-deficiency virus type 1. J. Leukocyte Biol. 56:362. 1994.

Kodihalli, S., Sivanandan V., Nagaraja, K.V., and Halvorson, D.A. Effect of avian influenza virus infection on the phagocytic function of systemic and pulmonary macrophages of turkeys. Avian Dis. 38:93-102. 1994.

Kodihalli, S., Sivanandan, V., Halvorson, D.A., and Nagaraja, K.V. Evaluation of the efficacy of an experimental avian influenza subunit vaccine in turkeys. Vaccine. 12:1467-1472. 1994.

1993

Lai, M-H.T., Tang, J., Wroblewski, V., Dee, A.G., Margolin, N., Vlahos, C., Bowdon, B., Buckheit, R.W., Jr., Colacino, J. and Hui, K.Y. Impeded progression of Friend disease in mice by an inhibitor of retroviral proteases. J. AIDS 6:24-31. 1993

McMahon, J.B., Gulakowski, R.J., Weislow, O.S., Schultz, R.J., Narayanan, V.L., Clanton, D.J., Pedemonte, R., Wassmundt, F.W.,Buckheit, R.W., Jr., Decker, W.D., White, E.L., Bader, J.P., and Boyd, M.R. Diarylsulfones, a new chemical class of nonnucleoside antiviral inhibitors of human immunodeficiency virus type 1 reverse transcriptase. Antimicrob. Agents Chemoth. 37:754-760. 1993.

Humblet, C.C., Lunney, E.A., Buckheit, R.W., Jr., Doggett, C., Wong, R. and Antonucci, T.K. Characterization of two structurally novel HIV-1 protease inhibitors identified by rational selection. Antiviral Research 21:73-84. 1993.

Kucera, L.S., Iyer, N.P., Puckett, S.H., Buckheit, R.W., Jr., Westbrook, L., Toyer, B.R., White, E.L., Germany-Decker, J.M., Shannon, W.M., Chen, R.C.-S., Nassiri, M.R., Shipman, C, Jr., Townsend L.B., and Drach, J.C. Activity of triciribine and triciribine-5′-monophosphate against human immunodeficiency virus types 1 and 2. AIDS Res. Hum. Retrov. 9:307-314. 1993.

Lai, M-H.T., Tang, J., Wroblewski, V., Dee, A.G., Margolin, N., Vlahos, C., Bowdon, B., Buckheit, R., Colacino, J. and Hui, K.Y. Impeded progression of Friend disease in mice by an inhibitor of retroviral proteases. J. AIDS 6:24-31. 1993

McMahon, J.B., Gulakowski, R.J., Weislow, O.S., Schultz, R.J., Narayanan, V.L., Clanton, D.J., Pedemonte, R., Wassmundt, F.W.,Buckheit, R.W., Jr., Decker, W.D., White, E.L., Bader, J.P., and Boyd, M.R. Diarylsulfones, a new chemical class of nonnucleoside antiviral inhibitors of human immunodeficiency virus type 1 reverse transcriptase. Antimicrob. Agents Chemoth. 37:754-760. 1993.

Humblet, C.C., Lunney, E.A., Buckheit, R.W., Jr., Doggett, C., Wong, R. and Antonucci, T.K. Characterization of two structurally novel HIV-1 protease inhibitors identified by rational selection. Antiviral Research 21:73-84. 1993.

Kucera, L.S., Iyer, N.P., Puckett, S.H., Buckheit, R.W., Jr., Westbrook, L., Toyer, B.R., White, E.L., Germany-Decker, J.M., Shannon, W.M., Chen, R.C.-S., Nassiri, M.R., Shipman, C, Jr., Townsend L.B., and Drach, J.C. Activity of triciribine and triciribine-5′-monophosphate against human immunodeficiency virus types 1 and 2. AIDS Res. Hum. Retrov. 9:307-314. 1993.

Buckheit, Jr., R.W., Hollingshead, M.G., Germany-Decker, J., White, E.L. McMahon, J.B., Allen, L.B., Ross, L.J., Decker, W.D., Westbrook, L., Shannon, W.M., Weislow, O.,Bader, J.P. and Boyd, M.R. Thiazolobenzimidazole: Biological and biochemical anti-retroviral activity of a nonnucleoside reverse transcriptase inhibitor. Antiviral Research. 21:247-266. 1993.

Buckheit, R.W., Jr., Germany-Decker, J., Hollingshead, M.G. Allen, L.B., Shannon, W.M., Janssen, P.A.J., and Chirigos, M.A. Differential antiviral activity of two TIBO derivatives against the human immunodeficiency and murine leukemia viruses alone and in combination with other anti-HIV agents. AIDS Res. Hum. Retrov. 9:1097-1106. 1993.

Williams, LL, Lewis, MG, Olsen, RG, Lafrado, LJ, Horrocks, LA, Rojko, JL. Chronic feline leukemia virus infection alters arachidonic acid proportions in vivo and in vitro. Proc.Soc.Exp.Biol.Med., 202:239-245. 1993

Black, PL, Lewis, MG, Petteway, SW, Lambert, D, Ussery, M, and Jahrling, PB. Inhibition of murine leukemia virus and simian immunodeficiency virus with an HIV protease inhibitor. Antimicrob. Agents Chemo.37:71-77, 1993

Shafferman, A, Lewis, MG, McCutchan, FE, Benveniste, RE, Jahrling, PB, Burke, DS and Eddy, GA. Prevention of transmission of simian immunodeficiency virus from vaccinated macaques that developed transient virus infection following challenge. Vaccine 11:848-852, 1993.

Novembre, FJ, Johnson, PR, Lewis, MG, Anderson, DC, Klumpp, S, McClure, HM and Hirsch, VM. Multiple viral determinants contribute to pathogenicity of the acutely lethal SIVsmmPBj variant. J. Virol. 67:2466-2474, 1993.

Rosenberg, YR, Zack, PM, White, BD, Papermaster, SF, Elkins, WR, Eddy, GA, and Lewis, MG. Decline in the CD4+ lymphocyte population in blood of SIV-infected macaques is not reflected in lymph nodes. AIDS Res. Human Retroviruses 9:639-646, 1993.

Lewis, MG, Elkins, WR, McCutchan, FE, Benveniste, RE, Lai, C-Y, Montefiori, DC, Burke, DS, Eddy, GE and Shafferman, A. Passively transfered antibodies directed against conserved regions of SIV envelope protect macaques from SIV infection. Vaccine 11:1347-1355, 1993.

Birx, DL, Lewis, MG, Zack, PM, Vahey, MA, Brown, CR, Redfield, RR, Burke, DL, Tosato, G and Jahrling, PB. Abnormally elevated serum levels of interleukin-6 in pigtailed macaques infected with SIV/sm/pbj. AIDS Res. Human Retroviruses 9:1123-1129, 1993.

Fletcher III, T.M., and Gray, W.L. DNA sequence and genetic organization of the unique short (Us) region of the simian varicella virus genome. Virology. 193: 762-773. 1993.

Gray, W.L., Gusick, N., Fletcher III, T.M., and Pumphrey, C.Y. Characterization and mapping of simian varicella virus transcripts. J. Gen. Virol. 74: 1639-1643. 1993.

Meltzer, M. S., Hoover, D. L., Finbloom, D. S., Turpin, J. A., Kalter, D. C., Friedman, R. M, Moyer, M. P., Nara P., and Gendelman, H. E. Mononuclear phagocytes in the pathogenesis of HIV disease. in: Mononuclear Phagocytes in Cell Biology, G. Lopez-Berestein and J. Klostergaard, Eds., CRC Press, Inc., Boca Raton, FL. p. 147. 1993.

Turpin, J. A. and Lopez-Berestein, G. Maturation and activation of human monocytes. in: Mononuclear Phagocytes in Cell Biology, G. Lopez-Berestein and J. Klostergaard, Eds., CRC Press, Inc., Boca Raton, FL. p. 71. 1993.

Kodihalli, S.Kodihalli, S., Sivanandan, V., D.A. Halvorson, V. , Nagaraja, K.V., and Kumar, M.C. Antigen capture ELISA for rapid diagnosis of avian influenza virus antigen in commercial turkey flocks. J. Vet. Diagn. Invest. 5: 438-440. 1993.

Kodihalli, S., Sivanandan, V. , Nagaraja, K.V., Goyal, S.M. and Halvorson, D.A. An enzyme immunoassay for detection of avian influenza virus antigen in turkeys. Am. J. Vet. Res. 54: 1385-1390. 1993.

1992

Gustafson, K.R., Cardellina, J. H. II., McMahon, J. B., Gulakowski, R. J., Ishitoya, J., Szallasi, Z., Lewin, N. E., Blumberg, P. M., Weislow, O. S., Beutler, J. A., Buckheit, R. W., Jr., Cragg, G. M., Cox, P. A., Bader, J. P. and Boyd, M. R. A nonpromoting phorbol from the Samoan medicinal plant Homalanthus mutans inhibits cell killing by HIV-1. J. Med. Chem. 35:1978-1986. 1992.

Corless, I.B., Lisker, A., and Buckheit, R.W., Jr. Decontamination of an HIV-contaminated CPR manikin. Am. J. Pub. Health. 82:1542-1543. 1992.

Clanton, D. J., Moran, R. A., McMahon, J. B., Weislow, O. S., Buckheit, R. W., Jr., Hollingshead, M. G., Ciminale, V., Felber, B.K., Pavlakis, G.N. and Bader, J. P. Sulfonic acid dyes: Inhibition of the human immunodeficiency virus and mechanism of action. AIDS Res. Hum. Retrov. 5:771-781. 1992.

Kashman, Y., Gustafson, K. R., Fuller, R. W., Cardellina, J. H. II, McMahon, J. B., Currens, M. J., Buckheit, R. W. Jr., Hughes, S. H., Cragg, G. M., and Boyd, M. R. The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree Calophyllum lanigerum. J. Med. Chem. 35:2735-2743. 1992.

Buckheit, R.W. Jr., Germany-Decker, J., Qualls-Goodwin, K., Bowdon, B.J. and Shannon, W.M. 3′-Azido-3′-deoxythymidine-induced reduction in the ability of uninfected CD4-expressing cells to participate in syncytium formation. Proc. Natl. Acad. Sci. USA. 89:8361-8365. 1992.

Buckheit, R.W., Jr., White, E.L., Shannon, W.M., Guerrero, A., Pivel, J.P., Carrasco, L., Leal, J.A., and Chirigos, M.A. Significant anti-HIV activity of new modified polyanionic polymers in vitro. Immunopharmacology and Immunotoxicology 14:707-721. 1992.

Swayze, E.E., Shannon, W.M., Buckheit, R.W., Jr., Wotring, L.L., Drach, J.C. and Townsend, L.B. Synthesis, antiproliferative, and antiviral evaluation of certain acyclic 6- substituted pyrrolo[2,3-D]-pyrimidine nucleoside analogs related to sangivamycin and toyocamycin. Nucleosides and Nucleotides 11:1507-1527. 1992.

Comber, R.N., Reynolds, R.C., Friedrich, J.D., Manguikian, R.A.,Buckheit, R.W. Jr., Truss, J.W., Shannon, W.M. and Secrist J.A. III 5,5-Disubstituted hydantoins: Syntheses and anti-HIV activity. J. Med. Chem. 35:3567-3572. 1992.

Pallansch, L.A., Lackman-Smith, C.S. and Gonda, M.A. The bovine immunodeficiency-like virus encodes factors which trans activate the long terminal repeat. J. Virol. 66:2647-2652. 1992.

Rosenberg, YR, Shafferman, A, White, BD, Papermaster, SF, Leon, E, Eddy, GA, Benveniste, R, Burke, DS and Lewis, MG. Variation in the CD4+ and CD8+ population in lymph nodes does not reflect that in the blood during SIVmne/E11s infection of macaques. J. Med. Primatol. 21:131-137. 1992

Lewis, MG, Zack, PM, and Jahrling, PB. Infection of rhesus and cynomolgus macaques with a rapidly fatal SIV isolate from sooty mangabeys (SIVsmm/pbj). AIDS Res. Human Retroviruses 8:1631-1639. 1992

Shafferman, A, Lewis, MG, McCutchan, FE, Benveniste, RE, Jahrling, PB, Burke, DS and Eddy, GE. Vaccination of macaques with SIV conserved envelope peptides suppressed infection and prevented disease progression and transmission. AIDS Res. Human Retroviruses 8:1483-1488. 1992

Fletcher III, T.M., and Gray, W.L. Characterization of immunogenic simian varicella virus polypeptides and determination of the antigenic cross-reactivity with varicella zoster virus. J. Gen. Virol. 73: 1202-1215. 1992.

Gray, W.L., Pumphrey, C.Y., Ruyechan, W.T. and Fletcher III, T.M. The simian varicella virus and varicella zoster virus genomes are similar in size and structure. Virology. 186: 562-572. 1992

Turpin, J. A., Vargo, M. and Meltzer, M. S. Enhanced HIV-1 replication in retinoid-treated monocytes: retinoid effects mediated through mechanisms related to cell differentiation and to a direct transcriptional action on viral gene expression. J. Immunol. 148:2539. 1992.

Mufson, R. A., Myers, C., Turpin, J. A. and Meltzer, M. S. Phorbol ester reduces constitutive nuclear NFB and inhibits HIV-1 production in human monocytes. J. Leukocyte Biol. 52:637. 1992.

Howard, O. M. Z., Dean, M.,, Young, H., Ramsburgh, M. Turpin, J. A.,Michiel B. Kelvin, D., Lee, L. and Farrar, W. Characterization of a class three tyrosine kinase. Oncogene 7:895. 1992.

Sivanandan, V., Halvorson D.A., Kodihalli, S., Laudert, E., Nagaraja, K.V., Goyal, S.M., Newman, J.A. and Pomeroy, B.S. Use of DAS-ELISA for avian influenza antigen detection. Proceedings of the Third International Symposium on Avian Influenza, Madison, Wisconsin, May 27-29, pp. 278-280, 1992.

Halvorson, D.A., Kodihalli, S., Laudert, E. , Newman, J.A., Pomeroy, Shaw B.S., and Sivanandan, V. Influenza in turkeys in the U.S.A. (1987-1991). Proceedings of the Third International Symposium on Avian Influenza, Madison, Wisconsin, May 27-29, pp. 32-43, 1992.

1991

Buckheit, R.W., Jr. and Swanstrom, R. Characterization of an HIV-1 isolate displaying an apparent absence of virion-associated reverse transcriptase activity. AIDS Res Hum Retrov. 7:295-302, 1991.

Parker, W.B., White, E.L., Shaddix, S.C., Ross, L.J., Buckheit, R.W., Jr., Germany, J.M., Secrist, J.A., III, Vince, R., and Shannon, W.M. Mechanism of inhibition of human immunodeficiency virus type I reverse transcriptase and human DNA polymerases by the 5′-triphosphates of carbovir, 3′- azido-3-deoxythymidine, 2′,3′-dideoxyguanosine, and 3-deoxthymidine. J. Biological Chemistry 266:1754-1762, 1991.

White, E. L., Buckheit, R. W., Jr., Ross, L. J., Germany, J. M., Andries, K., Pauwels, R., Janssen, P.A.J., Shannon, W. M. and Chirigos, M.A. A TIBO derivative, R82913, is a potent inhibitor of HIV-1 reverse transcriptase with heteropolymer templates. Antiviral Research 16:257-266, 1991.

Vickers, T., Baker, B. F., Cook, P. D., Zounes, M., Buckheit, R. W., Jr., Germany, J. and Ecker, D.J. Inhibition of HIV-LTR gene expression by oligonucleotides targeted to the TAR element. Nucleic Acids Research 19:3359-3368, 1991.

Rosenberg, YR, White, BD, Papermaster, SF, Zack, P, Jahrling, PB, Eddy, GA, Burke, DS and Lewis, MG. Variation in T lymphocyte activation and susceptibility to SIV/PBj-14 induced acute death in macaques. J. Med. Primatol. 20:206-210, 1991.

Shafferman, A, Jahrling, PB, Benveniste, RE, Lewis, MG, Phipps, T, McCutchan, F, Sadoff, J, Eddy, G, and Burke, DS. A peptide vaccine based on conserved epitopes of SIV inhibits proliferation of SIV challenge in macaques. Proc. Natl. Acad. Sci. USA 88:7126-7130, 1991.

Summers, J., P. Smith, M. Huang and M. Yu .Regulation and morphogenetic effects of mutations in the envelope proteins of an avian hepadnavirus. J.Virol. 65:1301-1317. 1991.

Huang, M. and J. Summers Infection initiated by the RNA genome of a DNA virus. J. Virol. 65:5435-5439. 1991.

Gendelman, H. E., Baca, L. M., Turpin, J. A., Kalter, D. C., Dieffenbach, C., Friedman, R. M. and Meltzer, M. S. Interactions between interferon and the human immunodeficiency virus. J. Exp. Pathol. 5:53. 1991.

Kalter, D. K., Nakamura, M., Turpin, J. A., Baca, L. M. Dieffenbach, C., Ralph, P., Gendelman, H. E., and Meltzer, M. S., Enhanced HIV replication in MCSF-treated monocytes. J. Immunol. 46:298. 1991.

Meltzer, M. S., Baca, L. M., Turpin, J. A., Kalter, D. C., Dieffenbach, C, Friedman, R. M and Gendelman, H. E. Subversion of the cytokine network of T cell-macrophage interaction by the human immunodeficiency virus. Prog. Leukocyte Biol. 11:205. 1991.

Wedrychowski, A., D. Seong, N. Paslidis, E. Johnson, O. Howard, M. Z.,Turpin, J.A., Talpaz, M., Kantarjian, H., Hester, J., Lopez-Berestein, G., Gutterman, J., Freireich E., and Deisseroth, A. Characterization of nuclear proteins which bind to interferon-inducible transcriptional elements in hematopoietic cells. J. Biol. Chem. 265:21433. 1991.

Turpin, J., Blick, M., Hester, J. P. and Lopez-Berestein, G. C-fos and TNF expression in human peripheral blood monocytes: expression is dependent on the stage of in vitro differentiation. Nat. Immun. Cell Growth Regul. 10:19. 1991.

Meltzer, M.S., Baca, L., Turpin, J. A., Kalter, D. C., Dieffenbach, C., Friedman, R. M. and Gendelman, H. E. Regulation of cytokine and viral gene expression in monocytes infected with the human immunodeficiency virus. Pathobiology 57:1. 1991.

Nelson, B. J., Belosevic, M., Green, S. J., Turpin, J. A. and Nacy, C. Interleukin-2 and the regulation of activated macrophage cytotoxic activities. Adv. Exp. Med. Biol. 319:77. 1991.

Gendelman, H. E., Friedman, R. M., Joe, S., Baca, L. M., Turpin, J. A.,Dveksler, G. Meltzer, M. S. and Dieffenbach, C. A selective defect of interferon alpha production in human immunodeficiency virus-infected monocytes. J. Exp. Med. 173:277. 1991.

Reuben, J., Gonik, B., Li, S., Loo, L. and Turpin, J. A. Induction of cytokines in normal placental cells by the human immunodeficiency virus. Lymphokines and Cytokine Res. 10:195. 1991.

Meltzer, M. S., Skillman, D. R., Hoover, D. L., Hansen, B. D., Turpin, J. A., D. C. Kalter and H. E. Gendelman. Macrophages and the human immunodeficiency virus. in: HIV and the Immune System Cambridge, England, Elsevier Trends Journals, p. 4. 1991.

1990

Pallansch, L.A., Beswick, H.,Talian,J. and Zelenka,P.S. Use of an RNA folding algorithm to choose regions for amplification by the polymerase chain reaction. Anal. Biochem. 185:57-72. 1990.

Gonda, M.A., Oberste, M.S, Garvey, K.J., Pallansch, L.A., J.K. Battles,L.A., Pifat, D.Y. Bess, J.W.Jr., and Nagashima, K. Development of the bovine immunodeficiency-like virus as a model of lentivirus disease. In Developments in Biological Standardization. S. Karger, Basel, Vol. 72, pp. 97-110. 1990.

Gonda, M.A., M.S. Oberste, K.J. Garvey, L.A. Pallansch, J.K. Battles, D.Y. Pifat, and K. Nagashima. Contemporary developments in the biology of the bovine immunodeficiency-like virus. In Animal Models in AIDS. H. Schellekens and M. Horzinek, eds. Elsevier Science Publishers B.V./Biomedical Division, Amsterdam, pp. 233-255. 1990.

Dezzutti, CS, Lafrado, LJ, Lewis, MG, and Olsen, RG. Inhibition of phorbol ester-induced neutrophil chemiluminescence by FeLV. Arch. Virol. 111:75-85, 1990.

Huang, M. and Xu, Z. Y. An epidemiological study on prevalence and risk factors of hepatitis B virus infection in preschool children. J. Chinese Epidemiol. 11:129-132. 1990.

Meltzer, M. S., Nakamura, M. Hansen B. D., Turpin, J. A., Kalter D. C. and Gendelman. H. EMacrophages as susceptible targets, persistent viral reservoirs in tissues, and key immunoregulatory cells that control levels of virus replication and extent of disease. AIDS Res. Hum. Retroviruses 6:967. 1990.

Gendelman, H., EBaca, L. M., Turpin, J. A.,  Kalter, D. C. Hansen, B. Friedman, J. M. Friedman R. M. and Meltzer M. S. Restriction of HIV replication in infected T cells and monocytes by interferon-. AIDS Res. Hum. Retroviruses 6:1045. 1990.

Meltzer, M. S., Skillman, D. R. Hoover, D. L. Hanson, B. D. Turpin J. A., Kalter D.C. and Gendelman. H. E. Macrophages and the human immunodeficiency virus. Immunol. Today 11:217. 1990.

Gendelman, H. E., Baca, L. M. Husayni, H. Turpin, J. A. Skillman D., Kalter, D. C., Orenstein, J. M. Hoover D. L. and Meltzer M. S.. Macrophage-HIV interaction: viral isolation and target cell isolation. AIDS(London) 4:221. 1990.

Turpin, J., Blick M., Mehta K. and Lopez-Berestein G. Effect of retinoic acid and retinol on TNF release and c-fos and TNF mRNA expression during human monocyte in vitro differentiation. J. Leukocyte Biol. 48:444. 1990.

Gendelman, H. E., Joe S.,. Baca L. M, Turpin, J. A. Dveksler, G. Friedman, R. M. Meltzer, M. S. and DieffenbachA C. A selective defect of IFNproduction in HIV infected monocytes. J. Exp. Med. 72:1433. . 1990.

Howard, O. M. Z., Talpaz, M., Kantarjian, H., Seong D., Wedrychowski, A., Paslidis, N., Hester, J., Cork, A., Turpin, J., Lopez-Berestein, G., Gutterman, J., Freireich E., and Deisseroth. A. Interferon affects nuclear proteins in cells of clinically sensitive chronic myelogenous leukemia patients. Blood 76:1117. 1990.

Gendelman, H. E., Baca, L. M., Turpin, J., Kalter, D. C., Hansen, B., Friedman, R. M., Dieffenbach,C., and Meltzer, M.S. Regulation of HIV replication in infected monocytes: mechanisms for interferon -induced viral restriction J. Immunol. 145:2669. 1990.

1989

Buckheit, R.W., Jr., Leiberman, S.N., Bolognesi, D.P., and Weinhold, K.J. The effects of leukemosuppressive immunotherapy on thymic infectious cell centers in AKR mice. Thymus 12:143-156, 1989.

Zelenka, P.S., Pallansch, L.A. and Vatal, M. Nuclear run-on transcription from primary embryonic lens tissue. Developmental Biology 132:69-72. 1989.

Dezzutti, CS, Wright, KA, Lewis, MG, Lafrado, LJ and Olsen, RG. FeLV-induced immunosuppression through alteration in signal transduction: Down regulation of protein kinase C. Vet. Immunol. Immunopathol. 21:55-67, 1989.

Wright, KA, Dezzutti, CS, Lewis, MG and Olsen, RG. FeLV-induced immunosuppression through alteration in signal transduction: Changes in intracellular free calcium levels. Vet. Immunol. Immunopathol. 21:47-53, 1989.

Lafrado, LJ, Dezzutti, CS, Lewis, MG and Olsen, RG. Immunodeficiency in latent feline leukemia virus infections. Vet. Immunol. Immunopathol. 21:39-46, 1989.

Lopez-Berestein, G., Turpin J., Hester, J. P., Gschwind C. and Reuben, . Effects of liposomal amphotericin B on human peripheral blood monocytes and lymphocytes. J. Liposome Res. 1:81. 1989.

Ventura, G. J., Hester, J. P., Swan, F., Vadhan, R. S., Turpin J. A., Dicke K. A. and Reading C. L.. Analysis of peripheral blood granulocyte macrophage colony growth by limiting dilution assay. Exp. Hematol. 17:125. 1989.

1988

Buckheit, R.W., Jr., Kurtzberg, J., Bolognesi, D.P. and Weinhold, K.J. The coenrichment of stem cells, prothymocytes, and stromal elements with ecotropic virus producing cells from the bone marrow of leukemia-prone AKR mice. Virology 162:354-361, 1988.

Buckheit, R.W., Jr., Bolognesi, D.P., and Weinhold, K.J. The role of bone marrow and thymic elements in the initiation and spread of leukemogenic virus production in the AKR thymus. Virology 166:533-541, 1988.

Pifat, Osterling, and Smith. Antigenic Analysis of Punta Toro virus and Identification of Protective Determinants with Monoclonal Antibody. Virology, Aug 1988.

Zelenka, P.S., Pallansch, L.A., Vatal M., and Nath, P. Proto-oncogene expression during in vitro differentiation of embryonic chicken lens epithelial explants. In Molecular Biology of the Eye: Genes, Vision and Ocular Disease. NEI-UCLA Symposium on Molecular and Cellular Biology, Vol. 58. J. Piatigorsky, P. Zelenka, and T. Shinohara, eds. Alan R. Liss, Inc., New York, NY, pp. 249-258. 1988.

Olsen, RG, Lewis, MG, Bauer, RM, Mathes, LE, Lafrado, LJ, Blakeslee, JR, and Tarr,MJ. Expression, release and characterization of soluble human T-lymphotropic virus-I (HTLV-I) antigens from an infected cell line. Cancer Detect. Prevent. 12:31-37, 1988.

Cox, CE, Orosz, C, Lewis, MG, Olsen, RG and Fertel, RH. Effect of 8-methoxypsoralen on human lymphocyte proliferation. Int. J. Immunopharmacol. 10:773-781, 1988.

Lewis, MG, Lafrado, LJ, Haffer, K, Gerber, J, Sharpee, RL and Olsen, RG. Feline leukemia virus vaccine: New developments. Vet. Micro. 17:297-308, 1988.

Yu, M., Xue, J. and Huang, M. Effect of prostaglandin (PG) E2 and F2a on the level of haptoglobin in rabbit. Zoological Res. (Chinese) 9:15-22. 1988.

Huang, M. and Xu, Z. Epidemiological studies of hepatitis B virus (HBV) infection and its prevention: Characteristics of HBV prevalence, incidence, risk factors and efficacy of intradermal. 1988.

1987

Buckheit, R.W., Jr., Bolognesi, D.P. and Weinhold, K.J. The effects of leukemosuppressive immunotherapy on bone marrow infectious cell centers in AKR mice. Virology 157:387-396, 1987.

Lafrado, LJ, Lewis, MG, Mathes, LE and Olsen, RG. Suppression of invitro neutrophil function by feline leukemia virus (FeLV) and purified FeLV-p15e. J Gen Virol 68:507-513, 1987.

Krakowka, S. Ringler, S, Lewis, MG and Olsen, RG. Immunosuppression by canine distemper virus: Production of in vitroimmunoglobulin synthesis, interleukin release and prostaglandin E2production. Vet. Immunol. Immunopath. 15:181-201, 1987.

Lewis, MG, Lafrado, LJ, Wright, KA, Shanker, J, Palumbo, NE, Lamoine, ED and Olsen, RG. Evaluation of the use of saliva as a source of feline leukemia virus antigen for diagnosis of disease. J. Clin. Micro. 25:1320-1322, 1987.

Mehta, K., Turpin, J. and Lopez-Berestein, G.. Induction of tissue transglutaminase in human peripheral blood monocytes by intracellular delivery of retinoids. J. Leukocyte Biol. 41:341. 1987.

Lautersztain, J., Perez-Soler, R., Turpin, J., Khokhar, A. R.,. Siddik, Z. H, Schmidt, K. and Lopez-Berestein, G.. Cellular pharmacology of liposomal cis-bis-neodecanoato-trans-R, R-1,2-diaminocyclohexane-platinum(II)(l-NDDP). Cancer Res. 48:1300. 1987.

1986

Nath, P., R. Getzenberg, D. Beebe, L. Pallansch, and P. Zelenka. c-myc mRNA is elevated as differentiating lens cells withdraw from the cell cycle. Exp. Cell Res. 169:215. 1986.

Mastro, JM, Lewis, MG, Mathes, LE, Sharpee, R, Tarr, MJ and Olsen, RG. Feline leukemia virus vaccine: Efficacy, content and probable mechanism. Vet. Immunol. Immunopath. 11:205-213, 1986.

Lewis, MG, Duska, DO, Stiff, MI, Lafrado, LJ and Olsen, RG. Polymorphonuclear leukocyte dysfunction associated with feline leukemia virus infection. J. Gen. Virol. 67:2113-2118, 1986.

Lewis, MG, Chang, JY, Fertel, RH and Olsen, RG. Calmodulin-like activity associated with retroviral virions. Biochem. Biophys. Res. Comm. 141:1077-1083, 1986.

Turpin, J., Hersh E. M. and Lopez-Berestein, G. Characterization of small and large human peripheral blood monocytes: effects of in vitro maturation on hydrogen peroxide release and on the response to macrophage activators. J. Immunol. 136:4194. 1986.

Klostergaard, J., Turpin, J. and Lopez-Berestein, G. Effector mechanisms of human monocyte-mediated tumor cytotoxicity in vitro: parameters of induction of cytotoxins from peripheral blood monocytes isolated by counterflow elutriation. Cancer Res. 46:662. 1986.

Klostergaard, J., Foster, W. A., Hamilton,D. A., Turpin, J. and Lopez-Berestein,G. Effector mechanisms of human monocyte-mediated tumor cytotoxicity in vitro: biochemical, functional and serological characteristics of cytotoxins produced by peripheral blood isolated by counterflow elutriation. Cancer Res. 46:2871. 1986.

Turpin, J., Hester, J. P.,. Hersh, E. M and Lopez-Berestein,G. Centrifugal elutriation as a method for isolation of large numbers of functionally intact human peripheral blood monocytes. J. Clin. Apheresis 3:111. 1986.

Takaue, Y., Roome, A. J., Turpin, J. A. and Reading, C. L. Depletion of T lymphocytes from human bone marrow by the use of counterflow elutriation centrifugation. Am. J. Hematol. 23:247. 1986.

1985

A Reliable Method for Recovery of Cryopreserved Hybridoma Cells.Osterling and Early, Journal of Tissue Culture Methods, Vol 9, No. 3, 1985.

Fusion of Mouse-Mouse Cells to Produce Hybridomas Secreting Monoclonal Antibody, Early and Osterling, Journal of Tissue Culture Methods, Vol 9, No. 3, 1985.

Lewis, MG, Kociba, GJ, Rojko, JL, Stiff, MI, Haberman, AB, Velicer, LF and Olsen, RG. Retroviral-associated eosinophilic leukemia in the cat. Am. J. Vet. Res. 46:1066-1070, 1985.

Lewis, MG, Fertel, RH and Olsen, RG. The reversal of feline retroviral-induced suppression of lymphocyte Con A receptor mobility by indomethacin and prostaglandin E2. Leukemia Res. 9:1105-1109, 1985.

Lewis, MG, Fertel, RH and Olsen, RG. The reversal of retrovirus suppression by indomethacin. Leukemia Res. 9:1451-1456, 1985.

1984

Wellman, ML, Kociba, GJ, Lewis, MG, Mathes, LE and Olsen, RG. Inhibition of erythroid colony-forming cells by a 15,000 dalton protein of feline leukemia virus. Cancer Res. 44:1527-1529, 1984

1983

Copelan, E, Lewis, M, Rinehart, J, Mathes, L, Olsen, R and Sagone, A. Suppression of human T lymphocyte proliferation by a structural protein of feline leukemia virus. J. Immunol. 131:2017-2020, 1983.

1981

Rice, JB, Schaller, JP, Lewis, MG, Mathes, LE, Hoover, EA and Olsen RG. Infection of feline embryo adherent cells with feline leukemia virus: Feline oncornavirus-associated cell membrane antigen expression and morphologic transformation. J. Natl. Cancer Inst. 66:89-96, 1981.

Lewis, MG, Mathes, LE and Olsen, RG. Protection against feline leukemia by vaccination with a subunit vaccine. Infect. Immun. 34:888-894, 1981.

1980

Olsen, RG, Lewis, MG, Mathes, LE and Hause, W. Feline leukemia vaccine: Efficacy testing in a large multicat household. Feline Practice 10:13-16, 1980.

Olsen, RG, Lewis, MG, Mathes, LE and Hause, W. New approach to feline leukemia immunoprevention: Soluble tumor cell vaccine. California Vet. 34:11-13, 1980.